Onsite - Standard Hours - Mon - Friday
Hi all this one is urgent hoping to shortlist by EOD Thursday 4/17 if possible thank you :)
Ideal: PHD is preferred or exceptional working experience with a MS. Review top 3 skillsets for technical skills.
1) PhD in Pharmacology, Biochemistry, Molecular Biology
2) Expertise in Enzymology, Ligand Binding Kinetics, and Mechanism-of-Action studies.
2a(experience in Binding & Functional activity-based Assays such as TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer), FP, PCR) Fluorescence Resonance ,Fluorescence Polarization , Polymerase Chain Reaction
3) Proficiency in Assay Development to Screen and Characterize covalent inhibitors is Plus
4) Experience in evaluation and implementing new technologies to enhance Screen capabilities and Assay Performance for Small Molecules
Most important:
*** is seeking a talented and motivated individual with expertise in enzymology and biochemical assay development to support small molecule drug discovery. The successful candidate should possess strong technical expertise & exceptional hands-on laboratory skills, have excellent written and oral communication skills, enjoy working in a fast-paced multi-functional team environment, and keep current with field of expertise, including literature and technology development.
Preferred Qualifications
• PhD in pharmacology, biochemistry, molecular biology, or a related discipline.
• Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies.
• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as TR-FRET, FP, PCR etc.
• Experience in evaluation and implementing new technologies to enhance screen capabilities and assay performance for small molecules and/or oligonucleotides
• Proficiency in assay development to screen and characterize covalent inhibitors is plus
• Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers.
• Expertise in handling, analyzing and visualizing assay data sets and proficient in software platform such as GraphPad Prism.
• Drug discovery research experience in diverse target classes is a plus but not required.
• Detail-oriented and analytical with excellent problem-solving skills.
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
Day to Day Responsibilities:
Contribute to the assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development and troubleshooting in support of small molecule drug discovery.
• Develop and execute biochemical assays and convert into high-throughput screening (HTS) format to enable HTS campaign and meet project goals.
• Apply sophisticated biochemical and biophysical assay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study.
• Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature.
• Strong data analysis capabilities and able to communicate and present research results and provide scientific and technical support.
• Collaborate with internal cross-functional teams and external partners to enable project progression
Azad Mishra
O (908) 315-0558 Ext 70889
E azad.mishra@aequor.com
